Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00382969" target="_blank" >RIV/67985823:_____/12:00382969 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin

Original language description

We report the inhibition of glycerol-3-phosphate- and succinate-dependent oxygen consumption rates by digitonin treatment. Our results show that the inhibition of oxygen consumption rates is recovered by the addition of exogenous synthetic analog of coenzyme Q idebenone (hydroxydecylubiquinone) and cytochrome c. Glycerol-3-phosphate oxidation rate is recovered to 148% of control values, whereas succinate-dependent oxidation rate only to 68%. Our findings might indicate the different mechanism of the electron transfer from two flavoprotein-dependent dehydrogenases (glycerol-3-phosphate and succinate dehydrogenases) localized on the outer and inner face of the inner mitochondrial membrane, respectively

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

259-265

UT code for WoS article

000306508000004

EID of the result in the Scopus database

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