Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00391725" target="_blank" >RIV/67985823:_____/13:00391725 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.biocel.2013.01.010" target="_blank" >http://dx.doi.org/10.1016/j.biocel.2013.01.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2013.01.010" target="_blank" >10.1016/j.biocel.2013.01.010</a>
Alternative languages
Result language
angličtina
Original language name
Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen
Original language description
Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we testedthe hypothesis that UCP2 provides feedback downregulation of oxidative stress in vivo via synergy with an H2O2-activated mitochondrial calcium-independent phospholipase A2 (mt-iPLA2). In this article we demonstarte for the first time that UCP2, functional due to fatty acids released by redox-activated mt-iPLA2gamma, suppresses mitochondrial superoxide production by its uncoupling action. In conclusion, H2O2-activated mt-iPLA2gamma and UCP2 act in concert to protect against oxidative stress
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biochemistry and Cell Biology
ISSN
1357-2725
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
816-825
UT code for WoS article
000317371300007
EID of the result in the Scopus database
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