Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00475702" target="_blank" >RIV/67985823:_____/17:00475702 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/nn.4505" target="_blank" >http://dx.doi.org/10.1038/nn.4505</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nn.4505" target="_blank" >10.1038/nn.4505</a>
Alternative languages
Result language
angličtina
Original language name
Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
Original language description
Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular model for learning and memory. Induction of classical LTP involves an NMDA-receptor-and calcium-dependent increase in functional synaptic AMPA receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic membrane. Here we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling and LTP. This pathway requires the metabotropic action of kainate receptors and activation of G protein, protein kinase C and phospholipase C. Like classical LTP, kainate-receptor-dependent LTP recruits recycling endosomes to spines, enhances synaptic recycling of AMPA receptors to increase their surface expression and elicits structural changes in spines, including increased growth and maturation. These data reveal a new and, to our knowledge, previously unsuspected role for postsynaptic kainate receptors in the induction of functional and structural plasticity in the hippocampus.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA17-02300S" target="_blank" >GA17-02300S: Molecular, cellular, and behavioral effects of NMDA receptor-modulating steroids</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Neuroscience
ISSN
1097-6256
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
529-539
UT code for WoS article
000397558800008
EID of the result in the Scopus database
2-s2.0-85012279012