Extracellular acidosis and high levels of carbon dioxide suppress synaptic transmission and prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F98%3A43901775" target="_blank" >RIV/00216208:11120/98:43901775 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/(SICI)1098-1063(1998)8:1<24::AID-HIPO3>3.0.CO;2-7" target="_blank" >http://dx.doi.org/10.1002/(SICI)1098-1063(1998)8:1<24::AID-HIPO3>3.0.CO;2-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/(SICI)1098-1063(1998)8:1<24::AID-HIPO3>3.0.CO;2-7" target="_blank" >10.1002/(SICI)1098-1063(1998)8:1<24::AID-HIPO3>3.0.CO;2-7</a>

Result language
angličtina
Original language name
Extracellular acidosis and high levels of carbon dioxide suppress synaptic transmission and prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices
Original language description
Long-term potentiation (LTP) is a long-lasting increase in synaptic strength induced by high frequency stimulation. LTP may participate in learning and memory formation, In many synaptic systems, LTP is dependent on intact function of M-methyl-D-aspartate (NMDA) receptors, NMDA receptors may be inhibited in different conditions involving also extracellular acidosis. A decrease in the extracellular pH accompanies many pathological states such as ischemia, hypoxia, and the CNS injury. The study was designed to determine whether comparable extracellular acid-base imbalances are able to interfere with the LTP induction. Hippocampal slices from adult rats were stimulated with high frequency stimulation (1 x 100 Hz/1 s) at Schaffer collateral-commissural synaptic system in the environment with different pH (6.7-7.8) and the field responses were recorded in CA1. Acidosis was achieved by supplying excessive CO2 or by HCO(3)(-)decrease in standard bicarbonate-containing buffer or by a direct ac
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GA305%2F95%2F0588" target="_blank" >GA305/95/0588: Extracellular pH modulates neuronal activity, neuronal plasticity and epileptic seizures</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
1998
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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