Participation of GABA(B) receptors in cortical postictal excitability in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00488631" target="_blank" >RIV/67985823:_____/18:00488631 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ejphar.2017.10.022" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2017.10.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejphar.2017.10.022" target="_blank" >10.1016/j.ejphar.2017.10.022</a>

Result language

angličtina

Original language name

Participation of GABA(B) receptors in cortical postictal excitability in immature rats

Original language description

Arrest of seizures is due to an active inhibition and is followed in mature brain by period of refractoriness markedly present one min after the end of seizures. To study changes in cortical excitability after epileptic seizures we used electrical stimulation of sensorimotor cortical area in immature rats - 25-day-old ones with mature postictal refractoriness and 12-day-old where postictal potentiation of afterdischarges (ADs) is present instead of refractoriness at one minute after the end of the conditioning AD. GABA(B) receptor antagonist CGP35348 was found to partly suppress postictal refractoriness. In present study not only an antagonist CGP46381 (3 and 10 mg/kg i.p.) but also positive allosteric modulator of GABA(B) receptors CGP7930 ( 20 and 40 mg/kg i.p.) were used to study the role of GABA(B) receptors in both age groups. They were injected immediately after testing AD and 10 min later the two stimulations were repeated. CGP46381 partly antagonized postictal refractoriness in 25-day-old rats but did not significantly affect ADs in 12-day-old animals. CGP7930 did not significantly change ADs duration in either age group. GABAB receptors participate in mechanism of postictal refractoriness but did not play an important role in 12-day-old rats where potentiation instead of refractoriness is present.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Pharmacology

ISSN

0014-2999

e-ISSN

—

Volume of the periodical

818

Issue of the periodical within the volume

Jan 5

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

26-29

UT code for WoS article

000418522900004

EID of the result in the Scopus database

2-s2.0-85032856330