The NA(v)1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00489199" target="_blank" >RIV/67985823:_____/18:00489199 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10372377
Result on the web
<a href="http://dx.doi.org/10.1007/s00109-017-1599-0" target="_blank" >http://dx.doi.org/10.1007/s00109-017-1599-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00109-017-1599-0" target="_blank" >10.1007/s00109-017-1599-0</a>
Alternative languages
Result language
angličtina
Original language name
The NA(v)1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing
Original language description
Controlling pain in burn-injured patients poses a major clinical challenge. Recent findings suggest that reducing the activity of the voltage-gated sodium channel Na(v)1.7 in primary sensory neurons could provide improved pain control in burn-injured patients. Here, we report that partial thickness scalding-type burn injury on the rat paw upregulates Na(v)1.7 expression in primary sensory neurons 3 h following injury. The injury also induces upregulation in phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB), a marker for nociceptive activation in primary sensory neurons. The upregulation in p-CREB occurs mainly in Na(v)1.7-immunopositive neurons and exhibits a peak at 5 min and, following a decline at 30 min, a gradual increase from 1 h post-injury. The Na(v)1.7 blocker protoxin II (ProTxII) or morphine injected intraperitoneally 15 min before or after the injury significantly reduces burn injury-induced spinal upregulation in phosphorylated serine 10 in histone H3 and phosphorylated extracellular signal-regulated kinase 1/2, which are both markers for spinal nociceptive processing. Further, ProTxII significantly reduces the frequency of spontaneous excitatory post-synaptic currents in spinal dorsal horn neurons following burn injury. Together, these findings indicate that using Na(v)1.7 blockers should be considered to control pain in burn injury.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Medicine-Jmm
ISSN
0946-2716
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
75-84
UT code for WoS article
000419131300008
EID of the result in the Scopus database
2-s2.0-85031925522