Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00537912" target="_blank" >RIV/67985823:_____/20:00537912 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/978-3-030-58677-5_15" target="_blank" >https://doi.org/10.1007/978-3-030-58677-5_15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-58677-5_15" target="_blank" >10.1007/978-3-030-58677-5_15</a>
Alternative languages
Result language
angličtina
Original language name
Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences
Original language description
It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium-induced swelling as compared with the male myocardium, this suggests their better protection against mitochodrial permeability transition pore (PTP) opening.It seems to us that sex-dependent specificity of the PTP function is not the results of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP compex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GJ19-04790Y" target="_blank" >GJ19-04790Y: Effect of perinatal hypoxia and low-protein diet on the role of RNA-demethylase FTO in the regulation of heart function and energy metabolism</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Sex Differences in Heart Disease
ISBN
978-3-030-58676-8
Number of pages of the result
9
Pages from-to
257-265
Number of pages of the book
284
Publisher name
Springer International Publishing
Place of publication
Cham
UT code for WoS chapter
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