Circadian regulation of transporter expression and implications for drug disposition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00542597" target="_blank" >RIV/67985823:_____/21:00542597 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/21:10439660

Result on the web

<a href="https://doi.org/10.1080/17425255.2021.1868438" target="_blank" >https://doi.org/10.1080/17425255.2021.1868438</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17425255.2021.1868438" target="_blank" >10.1080/17425255.2021.1868438</a>

Result language

angličtina

Original language name

Circadian regulation of transporter expression and implications for drug disposition

Original language description

Introduction: Solute Carrier (SLC) and ATP-binding cassette (ABC) transporters expressed in the intestine, liver, and kidney determine the absorption, distribution, and excretion of drugs. In addition, most molecular and cellular processes show circadian rhythmicity controlled by circadian clocks that leads to diurnal variations in the pharmacokinetics and pharmacodynamics of many drugs and affects their therapeutic efficacy and toxicity.Area covered: This review provides an overview of the current knowledge on the circadian rhythmicity of drug transporters and the molecular mechanisms of their circadian control. Evidence for coupling drug transporters to circadian oscillators and the plausible candidates conveying circadian clock signals to target drug transporters, particularly transcription factors operating as the output of clock genes, is discussed.Expert opinion: The circadian machinery has been demonstrated to interact with the uptake and efflux of various drug transporters. The evidence supports the concept that diurnal changes that affect drug transporters may influence the pharmacokinetics of the drugs. However, more systematic studies are required to better define the timing of pharmacologically important drug transporter regulation and determine tissue- and sex-dependent differences. Finally, the transfer of knowledge based on the results and conclusions obtained primarily from animal models will require careful validation before it is applied to humans.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/GA18-02993S" target="_blank" >GA18-02993S: The role of microbiota in the regulation of extra-adrenal steroidogenesis and local metabolism of glucococorticoids during stress</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Expert Opinion on Drug Metabolism & Toxicology

ISSN

1742-5255

e-ISSN

1744-7607

Volume of the periodical

17

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

425-439

UT code for WoS article

000604653900001

EID of the result in the Scopus database

2-s2.0-85098689413