Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2 gamma with Fatty Acid-Conducting SLC25 Gene Family Transporters

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00542843" target="_blank" >RIV/67985823:_____/21:00542843 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2076-3921/10/5/678" target="_blank" >https://www.mdpi.com/2076-3921/10/5/678</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antiox10050678" target="_blank" >10.3390/antiox10050678</a>

Result language

angličtina

Original language name

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2 gamma with Fatty Acid-Conducting SLC25 Gene Family Transporters

Original language description

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-independent phospholipase A2 gamma (iPLA2 gamma), is addressed to the mitochondrial matrix (or peroxisomes), where it may manifest its unique activity to cleave phospholipid side-chains from both sn-1 and sn-2 positions, consequently releasing either saturated or unsaturated fatty acids (FAs), including oxidized FAs. Moreover, iPLA2 gamma is directly stimulated by H2O2 and, hence, is activated by redox signaling or oxidative stress. This redox activation permits the antioxidant synergy with mitochondrial uncoupling proteins (UCPs) or other SLC25 mitochondrial carrier family members by FA-mediated protonophoretic activity, termed mild uncoupling, that leads to diminishing of mitochondrial superoxide formation. This mechanism allows for the maintenance of the steady-state redox status of the cell. Besides the antioxidant role, we review the relations of iPLA2 gamma to lipid peroxidation since iPLA2 gamma is alternatively activated by cardiolipin hydroperoxides and hypothetically by structural alterations of lipid bilayer due to lipid peroxidation. Other iPLA2 gamma roles include the remodeling of mitochondrial (or peroxisomal) membranes and the generation of specific lipid second messengers. Thus, for example, during FA beta-oxidation in pancreatic beta-cells, H2O2-activated iPLA2 gamma supplies the GPR40 metabotropic FA receptor to amplify FA-stimulated insulin secretion. Cytoprotective roles of iPLA2 gamma in the heart and brain are also discussed.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LTAUSA17174" target="_blank" >LTAUSA17174: The role of antioxidants and mitochondrial phospholipase iPLA2γ in the protection against cerebral ischemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Antioxidants

ISSN

2076-3921

e-ISSN

2076-3921

Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

678

UT code for WoS article

000653353600001

EID of the result in the Scopus database

2-s2.0-85104625325