H2O2-Activated Mitochondrial Phospholipase iPLA2 gamma Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic beta-Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00451864" target="_blank" >RIV/67985823:_____/15:00451864 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/ars.2014.6195" target="_blank" >http://dx.doi.org/10.1089/ars.2014.6195</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/ars.2014.6195" target="_blank" >10.1089/ars.2014.6195</a>
Alternative languages
Result language
angličtina
Original language name
H2O2-Activated Mitochondrial Phospholipase iPLA2 gamma Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic beta-Cells
Original language description
When directly stimulated by hydrogen peroxide, the mitochondrial phospholipase iPLA2 gamma cleaves fatty acids to initiate uncoupling mediated by UCP2, which then attenuates mitochondrial superoxide formation. The synergy of iPLA2 gamma and UCP2 thus leads to cytoprotection. Moreover, fatty acid beta oxidation initiates iPLA2 gamma cleavage of mitochondrial fatty acids which spread up to the plasma membrane and activate G-protein coupled receptor-40 (GPR40) that subsequently initiates insulin secretionby so-called glycerolipid/fatty acid cycle
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants & Redox Signaling
ISSN
1523-0864
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
958-972
UT code for WoS article
000363925700002
EID of the result in the Scopus database
2-s2.0-84945956960