Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00542997" target="_blank" >RIV/67985823:_____/21:00542997 - isvavai.cz</a>

Alternative codes found

RIV/67985530:_____/21:00542997 RIV/61389013:_____/21:00542997

Result on the web

<a href="https://www.mdpi.com/2073-4360/13/11/1871" target="_blank" >https://www.mdpi.com/2073-4360/13/11/1871</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym13111871" target="_blank" >10.3390/polym13111871</a>

Result language

angličtina

Original language name

Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering

Original language description

Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold. The shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds. However, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/GA20-07015S" target="_blank" >GA20-07015S: Magnetic Composite Materials for Non-Invasive Cell Stimulation in Tissue Engineering</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymers

ISSN

2073-4360

e-ISSN

2073-4360

Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1871

UT code for WoS article

000660535800001

EID of the result in the Scopus database

2-s2.0-85108223800