Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00583231" target="_blank" >RIV/67985823:_____/24:00583231 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10451378 RIV/00064165:_____/24:10451378
Result on the web
<a href="https://doi.org/10.1002/dvdy.552" target="_blank" >https://doi.org/10.1002/dvdy.552</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/dvdy.552" target="_blank" >10.1002/dvdy.552</a>
Alternative languages
Result language
angličtina
Original language name
Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
Original language description
Background:The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function in mammalian and avian embryos was poorly addressed.Results:We simulated impulse propagation inside the looping ventricle and revealed delayed apical activation in the heart with inhibited trabecular growth. This finding was corroborated by direct imaging of the endocardial surface showing early activation within the trabeculae implying preferential spreading of depolarization along with them. Targeting two crucial pathways of trabecular formation (Neuregulin/ErbB and Nkx2.5), we showed that trabecular development is also essential for proper conduction patterning. Persistence of the slow isotropic conduction likely contributed to the pumping failure in the trabeculae-deficient hearts.Conclusions:Our results showed the essential role of trabeculae in intraventricular impulse spreading and conduction patterning in the early endothermic heart. Lack of trabeculae leads to the failure of conduction parameters differentiation resulting in primitive ventricular activation with consequent impact on the cardiac pumping function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental Dynamics
ISSN
1058-8388
e-ISSN
1097-0177
Volume of the periodical
253
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
78-90
UT code for WoS article
000891509100001
EID of the result in the Scopus database
2-s2.0-85142921151