Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00604926" target="_blank" >RIV/67985823:_____/25:00604926 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/25:00604926
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/all.16426" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/all.16426</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.16426" target="_blank" >10.1111/all.16426</a>
Alternative languages
Result language
angličtina
Original language name
Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation
Original language description
CD53 is a pan-leukocyte tetraspanin implicated in asthma risk through genome-wide association studies. This study investigates the role of CD53 in IgE-antigen-mediated activation of mast cells and a preclinical mouse model of ovalbumin-induced allergic asthma. Bone marrow-derived mast cells from Cd53-deficient (Cd53-/-) and wild-type (WT) mice were used to examine antigen-IgE-induced mast cell responses. CD53 deficiency did not affect mast cell degranulation but significantly enhanced IgE-antigen-dependent production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-13. Mechanistically, CD53 deficiency prolonged phosphorylation of c-Jun N-terminal kinase (JNK) and increased nuclear factor-κB (NF-κB) activation. In vivo, using a type 2 allergic asthma model, the absence of CD53 resulted in reduced pulmonary leukocyte infiltration and IgE production but increased mucin gene expression. These changes correlated with impaired lung function measures, including increased tissue damping and elastance. These findings suggest that CD53 plays complex and multifaceted roles in asthma, promoting inflammatory leukocyte recruitment and IgE production while negatively regulating mucus production. In mast cells, CD53 appears to limit IgE-antigen-dependent cytokine production via signaling pathways involving NF-κB and JNK
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Allergy
ISSN
0105-4538
e-ISSN
1398-9995
Volume of the periodical
80
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1127-1131
UT code for WoS article
001375442900001
EID of the result in the Scopus database
2-s2.0-85211155709