CA1 ensembles expressing immediate-early genes are driven by context switch, shrink with sustained presence, and show no effect of change of task demands
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00616483" target="_blank" >RIV/67985823:_____/25:00616483 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43927812
Result on the web
<a href="https://doi.org/10.1016/j.bbr.2024.115407" target="_blank" >https://doi.org/10.1016/j.bbr.2024.115407</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2024.115407" target="_blank" >10.1016/j.bbr.2024.115407</a>
Alternative languages
Result language
angličtina
Original language name
CA1 ensembles expressing immediate-early genes are driven by context switch, shrink with sustained presence, and show no effect of change of task demands
Original language description
The hippocampus (HPC) is essential for navigation and memory, tracking environmental continuity and change, including navigation relative to moving targets. CA1 ensembles expressing immediate-early gene (IEG) Arc and Homer1a RNA are contextually specific. While IEG expression correlates with HPC-dependent task demands, the effects of behavioral demands on IEG-expressing ensembles remain unclear. In three experiments, we investigated the effects of context switch, sustained presence, and task demands on dorso-proximal CA1 IEG+ ensembles in rats.Experiment 1 showed that the size of IEG+ (Arc, Homer1a RNA) ensembles dropped to baseline during uninterrupted 30-min exploration, reflecting familiarization, unless a context switch was present. Context-specificity of the ensembles depended on both environment identity and timing of the context switch. Experiment 2 found no effect of HPC-dependent mobile robot avoidance or HPC-independent avoidance of a stationary robot on IEG+ ensembles beyond mere exploration. Experiment 3 replicated these findings for c-Fos protein.The data suggest that IEG+ ensembles are driven by a context switch and shrink over time during sustained presence in the same environment. We found no evidence of task demands or their change affecting the size, stability over time, or task-specificity of IEG+ ensembles.These results shed light on the temporal dynamics of CA1 IEG+ ensembles, and their control by contextual and behavioral factors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Behavioural Brain Research
ISSN
0166-4328
e-ISSN
1872-7549
Volume of the periodical
480
Issue of the periodical within the volume
5 March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
17
Pages from-to
115407
UT code for WoS article
001410438700001
EID of the result in the Scopus database
2-s2.0-85213852929