Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F22%3A00561869" target="_blank" >RIV/67985858:_____/22:00561869 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/22:43925223

Result on the web

<a href="https://hdl.handle.net/11104/0334333" target="_blank" >https://hdl.handle.net/11104/0334333</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seppur.2022.121050" target="_blank" >10.1016/j.seppur.2022.121050</a>

Result language

angličtina

Original language name

Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

Original language description

Small-scale, continuous separation and purification of fine chemicals of pharmaceutical value represent a challenging engineering task. Currently available slug-flow and parallel-flow microfluidic extractors suffer from instabilities of the liquid-liquid interface and difficult realization of the counter-current arrangement. To tackle this challenge, we constructed a robust microfluidic membrane extractor, which was realized as a membrane tube-in-a-shell system operating in a wide range of extraction conditions. We tested the microextractor performance on separating 7-aminodeacetoxycephalosporanic acid (7-ADCA), an essential precursor of beta-lactam antibiotics. Aqueous two-phase system (ATPS) and a system of identical aqueous phases were used in a series of extraction experiments. Expectedly, we found that the counter-current arrangement provides an almost 100 % yield of 7-ADCA. The enhanced 7-ADCA enrichment anticipated in the selected ATPS thanks to favorable 7-ADCA partitioning was only reached at longer residence times. Lower mass transport resistances occurring in low viscous aqueous phases turned out to have a primary effect on the extraction characteristics. A detailed analysis of transport resistances also revealed that the contribution of the tubular membrane to the overall mass transport resistance is low. This important finding indicates that microcontactors with thin integrated membranes are a promising option for micro-or milli-plants when fine chemicals are continuously produced.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA20-09980S" target="_blank" >GA20-09980S: Microfluidic reactors with embedded semi-permeable membranes for the preparation of special chemicals</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Separation and Purification Technology

ISSN

1383-5866

e-ISSN

1873-3794

Volume of the periodical

292

Issue of the periodical within the volume

JUL 1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

121050

UT code for WoS article

000855029400004

EID of the result in the Scopus database

2-s2.0-85128280496