Bioaccumulation of psychoactive contaminants and their effects on brain–gonad–sperm neurotransmitter networks in fish
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F25%3A00643137" target="_blank" >RIV/67985874:_____/25:00643137 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12520/25:43910170
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.est.5c07762" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.est.5c07762</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.est.5c07762" target="_blank" >10.1021/acs.est.5c07762</a>
Alternative languages
Result language
angličtina
Original language name
Bioaccumulation of psychoactive contaminants and their effects on brain–gonad–sperm neurotransmitter networks in fish
Original language description
Psychoactive compounds (PSYCs) in aquatic environments raise concern due to the evolutionary conservation of neurotransmitter systems across vertebrates. While their potential to affect neural function is increasingly recognized, much less is known about their influence on fish reproduction, which relies on neurotransmitters both via the brain−gonadal axis and directly within sperm, independent of neural control. Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. Neurotransmitter levels were quantified in brain, gonads, and sperm using LC−HRMS/MS, accompanied by bioaccumulation assessment, histopathology, and sperm quality analysis. All tested compounds bioaccumulated in brain and gonads and, notably, in sperm. Exposure to PSYCs modified neurotransmitter levels across tissues, disrupting correlation patterns between neurochemicals in brain, gonads, and sperm. No significant changes were observed in gonadal histopathology or sperm-quality parameters. However, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain−gonad−sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
<a href="/en/project/GA22-03754S" target="_blank" >GA22-03754S: From brain to sperm: how psychoactive pollutants can affect fish sperm function.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science & Technology
ISSN
0013-936X
e-ISSN
1520-5851
Volume of the periodical
59
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
27556-27571
UT code for WoS article
001634105100001
EID of the result in the Scopus database
2-s2.0-105025206802