Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F15%3A00457459" target="_blank" >RIV/67985882:_____/15:00457459 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1364/OE.23.020132" target="_blank" >http://dx.doi.org/10.1364/OE.23.020132</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1364/OE.23.020132" target="_blank" >10.1364/OE.23.020132</a>
Alternative languages
Result language
angličtina
Original language name
Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
Original language description
A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA](n) multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 degrees C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Ourfindings underscore the importance of conducting drug release studies in physiologically relevant conditions
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JA - Electronics and optoelectronics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH11038" target="_blank" >LH11038: Chemical and biochemical sensors based on functionalized micro- and nanostructured optical waveguides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Optics Express
ISSN
1094-4087
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
20132-20142
UT code for WoS article
000361035300151
EID of the result in the Scopus database
2-s2.0-84954473447