In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F15%3A00457461" target="_blank" >RIV/67985882:_____/15:00457461 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1117/12.2191683" target="_blank" >http://dx.doi.org/10.1117/12.2191683</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1117/12.2191683" target="_blank" >10.1117/12.2191683</a>

Result language
angličtina
Original language name
In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions
Original language description
The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release.We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a rangeof dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multil
Czech name
—
Czech description
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Project
<a href="/en/project/LH11038" target="_blank" >LH11038: Chemical and biochemical sensors based on functionalized micro- and nanostructured optical waveguides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of SPIE - FIBER OPTIC SENSORS AND APPLICATIONS XII
ISBN
978-1-62841-596-4
ISSN
0277-786X
e-ISSN
—
Number of pages
9
Pages from-to
9480051-9480059
Publisher name
SPIE
Place of publication
Washington
Event location
Baltimore
Event date
Apr 22, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000357019100004

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