Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F17%3A00488294" target="_blank" >RIV/67985882:_____/17:00488294 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >http://dx.doi.org/10.1117/12.2252816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2252816" target="_blank" >10.1117/12.2252816</a>

Result language

angličtina

Original language name

Silica nanoparticle coated long-period grating for in situ monitoring of drug delivery thin films

Original language description

Dielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin filmDielectric nanoparticle in integration with the long-period grating (LPG) is explored and its effect on the sensitivity is evaluated in the in situ monitoring of the deposition of drug delivery thin film. SiNPs were immobilized on the LPG via layer-by-layer self-assembly using poly allylamine hydrochloride (PAH). Theoretical calculation reveals that the SiNPs coating increases the evanescent field overlap in the surrounding of the LPG thus enhances its sensitivity. The increased total surface for the following thin film deposition also contributes to the enhancement of the sensitivity. Its unique capability for the in-situ monitoring of drug delivery thin film [chitosan (CHI) / Poly arylic acid (PAA) / Gentamicin sulfate (GS) / PAA](n) through layer-by-layer assembly (LbL) was demonstrated with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SiNPs with 50 nm in diameter. The sensitivity enhancement of the LPG also depends heavily on the layer numbers and sizes of the SiNPs. The LPG with SiNPs of 8 layer numbers exhibits a sensitivity of only 1.2 nm shift/tetralayer. Control experiment of LPG without the SiNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer. This investigation suggests that SiNPs are effective in fine tune the optical property of the LPG. SiNPs coating thick enough can be used as an effective insulation for LPG from outer species. This investigation sets up the foundation for the development of SiNPs enabled optical fiber LPG sensor for the in-situ study of drug delivery LbL thin film

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

<a href="/en/project/LH11038" target="_blank" >LH11038: Chemical and biochemical sensors based on functionalized micro- and nanostructured optical waveguides</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS XVII

ISBN

978-151060557-2

ISSN

0277-786X

e-ISSN

2410-9045

Number of pages

16

Pages from-to

—

Publisher name

SPIE

Place of publication

Bellingham

Event location

San Francisco

Event date

Jan 28, 2017

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000406420600007