Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F21%3A00542711" target="_blank" >RIV/67985891:_____/21:00542711 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21220/21:00357107 RIV/65269705:_____/21:00074474 RIV/00216305:26620/21:PU142047 RIV/00216224:14110/21:00122157

Result on the web

<a href="https://actavet.vfu.cz/90/1/0069/" target="_blank" >https://actavet.vfu.cz/90/1/0069/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202190010069" target="_blank" >10.2754/avb202190010069</a>

Result language

angličtina

Original language name

Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model

Original language description

The main goal of this study was to assess the progress of vertebral stability after lumbar interbody fusion related to microcomputed tomography (micro CT), biomechanical analysis, and histological assessment towards spine fusion. Twelve male pigs were used, each underwent L2-3 discectomy and implantation of an iliac crest bone graft in two groups, six spines were harvested eight weeks (A1) and six spines 16 weeks (A2) after surgery (7 native spines for biomechanical analysis). The CT was performed by GE phoenix datos|x 2.0 with a sample drift correction. The samples were divided according to fusion quality. Biomechanical evaluation was carried out on the MTS Mini Bionix testing system. In the nondestructive mode, three cycles of pure bending moments were applied (5 Nm load limit) at a rate of 20 °/min in flexion (+40 °) and extension (-40 °). Two representative histological sections from four samples were obtained (A1, n = 2, A2, n = 2), areas of mature bone were quantified. In micro CT, better results were achieved in group A2 (not significant). Eight weeks after the operation, flexural stiffness decreased to 48% of its initial value for native cadavers (P < 0.05), after 16 weeks it was comparable to native cadavers, demonstrating the suitability of the implanted graft (P < 0.05). The newly formed bone tissue occupied an average area of 94.205 mm (A1) and 26.240 mm (A2). It was confirmed that micro CT, biomechanical analysis, and histological assessment are technically feasible and suitable for the evaluation of results of other methods of large bone defect treatment. 2 2

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/NV17-31276A" target="_blank" >NV17-31276A: Comprehensive pre-clinical evaluation of lateral lumbar spine fusion with hybrid biodegradable nanocomposite porous implant.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

1801-7576

Volume of the periodical

90

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

69-75

UT code for WoS article

000654628800009

EID of the result in the Scopus database

2-s2.0-85104823198