Various Simulated Body Fluids Lead to Significant Differences in Collagen Tissue Engineering Scaffolds
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F21%3A00545906" target="_blank" >RIV/67985891:_____/21:00545906 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/21:10247779 RIV/00216208:11110/21:10432407 RIV/00064165:_____/21:10432407 RIV/68407700:21220/21:00357640
Result on the web
<a href="https://www.mdpi.com/1996-1944/14/16/4388" target="_blank" >https://www.mdpi.com/1996-1944/14/16/4388</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ma14164388" target="_blank" >10.3390/ma14164388</a>
Alternative languages
Result language
angličtina
Original language name
Various Simulated Body Fluids Lead to Significant Differences in Collagen Tissue Engineering Scaffolds
Original language description
This study aims to point out the main drawback with respect to the design of simulated body environments. Three media commonly used for the simulation of the identical body environment were selected, i.e., Kokubo's simulated body fluid that simulates the inorganic component of human blood plasma, human blood plasma, and phosphate buffer saline. A comparison was performed of the effects of the media on collagen scaffolds. The mechanical and structural effects of the media were determined via the application of compression mechanical tests, the determination of mass loss, and image and micro-CT analyses. The adsorption of various components from the media was characterized employing energy-dispersive spectrometry. The phase composition of the materials before and after exposure was determined using X-ray diffraction. Infrared spectroscopy was employed for the interpretation of changes in the collagen secondary structure. Major differences in terms of the mechanical properties and mass loss were observed between the three media. Conversely, only minor structural changes were detected. Since no general recommendation exists for selecting the simulated body environment, it is necessary to avoid the simplification of the results and, ideally, to utilize alternative methods to describe the various aspects of degradation processes that occur in the media.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/NV19-02-00068" target="_blank" >NV19-02-00068: Bioartificial cardiovascular patches and vessels from porcine collagen reinforced with nano/microfibers using stem cells and dynamic culture</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials
ISSN
1996-1944
e-ISSN
1996-1944
Volume of the periodical
14
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
4388
UT code for WoS article
000689353200001
EID of the result in the Scopus database
2-s2.0-85112339823