Behaviour of titanium dioxide particles in artificial body fluids and human blood plasma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F21%3A63542538" target="_blank" >RIV/70883521:28110/21:63542538 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/21:63542538
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/19/10614" target="_blank" >https://www.mdpi.com/1422-0067/22/19/10614</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms221910614" target="_blank" >10.3390/ijms221910614</a>

Result language
angličtina
Original language name
Behaviour of titanium dioxide particles in artificial body fluids and human blood plasma
Original language description
The growing application of materials containing TiO2 particles has led to an increased risk of human exposure, while a gap in knowledge about the possible adverse effects of TiO2 still exists. In this work, TiO2 particles of rutile, anatase, and their commercial mixture were exposed to various environments, including simulated gastric fluids and human blood plasma (both representing in vivo conditions), and media used in in vitro experiments. Simulated body fluids of different com-positions, ionic strengths, and pH were used, and the impact of the absence or presence of chosen enzymes was investigated. The physicochemical properties and agglomeration of TiO2 in these media were determined. The time dependent agglomeration of TiO2 related to the type of TiO2, and mainly to the type and composition of the environment that was observed. The presence of enzymes either prevented or promoted TiO2 agglomeration. TiO2 was also observed to exhibit concentration-dependent cytotoxicity. This knowledge about TiO2 behavior in all the abovementioned environments is critical when TiO2 safety is considered, especially with respect to the significant impact of the presence of proteins and size‐related cytotoxicity.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project
<a href="/en/project/GA20-28732S" target="_blank" >GA20-28732S: Colloidal systems for topical formulations. Pickering emulsions and polymer based colloids.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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