Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00440351" target="_blank" >RIV/67985904:_____/15:00440351 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/15:#0001287 RIV/68378050:_____/15:00440351

Result on the web

<a href="http://dx.doi.org/10.1038/ncomms7078" target="_blank" >http://dx.doi.org/10.1038/ncomms7078</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ncomms7078" target="_blank" >10.1038/ncomms7078</a>

Result language

angličtina

Original language name

Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway

Original language description

The fully-grown mammalian oocyte is transcriptionally quiescent and utilizes only transcripts synthesized and stored during early development. However, we find that an abundant RNA population is retained in the oocyte nucleus and contains specific mRNAs important for meiotic progression. During the first meiotic division, shortly after nuclear envelope breakdown, translational hotspots develop in the chromosomal area and in a region that previously surrounded the nucleus. These distinct translational hotspots are separated by endoplasmic reticulum and Lamin, and disappear following polar body extrusion. Chromosomal translational hotspots are controlled by the activity of the mTOR–eIF4F pathway. Here, we reveal a mechanism that—following the resumption of meiosis—controls the temporal and spatial translation of a specific set of transcripts required for normal spindle assembly, chromosome alignment and segregation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications

ISSN

2041-1723

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

6078

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000348831300005

EID of the result in the Scopus database

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