Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00510249" target="_blank" >RIV/67985904:_____/19:00510249 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10403768
Result on the web
<a href="https://www.nature.com/articles/s41598-019-49483-5" target="_blank" >https://www.nature.com/articles/s41598-019-49483-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-019-49483-5" target="_blank" >10.1038/s41598-019-49483-5</a>
Alternative languages
Result language
angličtina
Original language name
Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes
Original language description
In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization, and translation. A subset of maternal transcripts is stored in a translationally dormant state in the oocyte, and temporally driven translation of specific mRNAs propel meiotic progression, oocyte-to-embryo transition and early embryo development. We identified Ank2.3 as the only transcript variant present in the mouse oocyte and discovered that it is translated after nuclear envelope breakdown. Here we show that Ank2.3 mRNA is localized in higher concentration in the oocyte nucleoplasm and, after nuclear envelope breakdown, in the newly forming spindle where its translation occurs. Furthermore, we reveal that Ank2.3 mRNA contains an oligo-pyrimidine motif at 5'UTR that predetermines its translation through a cap-dependent pathway. Lastly, we show that prevention of ANK2 translation leads to abnormalities in oocyte cytokinesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
SEP 11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
13121
UT code for WoS article
000485215800009
EID of the result in the Scopus database
2-s2.0-85072107368