The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00488578" target="_blank" >RIV/67985904:_____/18:00488578 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/18:00102403

Result on the web

<a href="http://dx.doi.org/10.1017/S0007114517003981" target="_blank" >http://dx.doi.org/10.1017/S0007114517003981</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0007114517003981" target="_blank" >10.1017/S0007114517003981</a>

Result language

angličtina

Original language name

The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults

Original language description

Recent evidence has raised the possibility of the existence of a sixth taste modality - that is, taste for fat - which is mediated by lingual CD36 and plays a role in obesity. Consequently, the genetic polymorphism of CD36 has been shown to be associated with altered oro-sensory detection of dietary lipids. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We also sequenced 5 and 6 exons of CD36 to trace out any new mutation that might be responsible for the difference in taste perception. We observed that craving for dietary lipids was correlated with anthropometric parameters (P<0.05) and LA detection threshold (P=0.033). The participants with the CC genotype of the rs1527483 polymorphism had lower BMI (P=0.011), waist circumference (P=0.005), waist:height ratio (P=0.010) and higher sensitivity for LA (P=0.037) than the participants with the CT and TT genotypes. Interestingly, we did not observe any association between the rs3212018 polymorphism and the studied parameters. Moreover, we did not observe any mutation in exons 5 and 6 of the CD36 gene in these subjects. Finally, we can state that rs1527483, but not rs3212018, is associated with high body weight in young Czech subjects.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Nutrition

ISSN

0007-1145

e-ISSN

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Volume of the periodical

119

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

472-478

UT code for WoS article

000426662500013

EID of the result in the Scopus database

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