Retinal abnormatilites as a diagnostic or prognostic marker of schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00495782" target="_blank" >RIV/67985904:_____/18:00495782 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/18:00106671 RIV/00179906:_____/18:10379398 RIV/00216208:11150/18:10379398
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2018.035" target="_blank" >http://dx.doi.org/10.5507/bp.2018.035</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.035" target="_blank" >10.5507/bp.2018.035</a>
Alternative languages
Result language
angličtina
Original language name
Retinal abnormatilites as a diagnostic or prognostic marker of schizophrenia
Original language description
The review is a summary of structural and functional changes in the human retina observed in patients with schizophrenia. The main focus is on the potential of these changes to serve as schizophrenia-specific biomarkers accessible to clinicians. We identified three features of the retina that can be detected non-invasively in humans and which appear to show charateristic changes in schizophrenia: (1) retinal microvasculature displaying abnormally wide venules, (2) electroretinograms indicating altered function of photoreceptors or other cells in the retinal component of the visual pathway, (3) optical coherence tomography pointing to structural differences between the retinae of patients with schizophrenia and those of healthy volunteers. We propose that the most feasible approach to evaluating the data would be to study the genetic and epigenetic background of the schizophrenia-associated retinal abnormalities and establish their significance and specificity as potential biomarkers for the disease. The studies should include longitudinal observations focusing on the possible involvement of medication and comorbid conditions in the mechanism of the disease, a comparison of schizophrenia with other mental disorders, and investigating retinal abnormalities in animal models of psychoses. Biomarkers identified in the process could represent an important addition to the arsenal of non-invasive techniques available to both clinicians and researchers. These novel biomarkers could facilitate research of the biological basis of psychosis and help to address the diagnostic, predicitive, preventative, prophylactic and therapeutic aspects of schizophrenia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
<a href="/en/project/NV16-27243A" target="_blank" >NV16-27243A: Microvascular abnormality as an endophenotype of schizophrenia</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
162
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
159-164
UT code for WoS article
000445913000001
EID of the result in the Scopus database
2-s2.0-85053732474