Double-strand DNA breaks response and Huntington´s disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536494" target="_blank" >RIV/67985904:_____/20:00536494 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Double-strand DNA breaks response and Huntington´s disease
Original language description
Double-strand DNA breaks (DSBs) are considered as the most harmful DNA lesions, as only one unrepaired DSB is sufficient to trigger chromosomal rearrangements, senescence, or cell death. In recent years, it was proposed that alterations in response to DSBs could contribute to pathology of neurodegenerative diseases, including Huntington's disease. Huntington's disease is a neurodegenerative disorder caused by the expansion of CAG trinucleotide repeats in the huntingtin gene giving rise to mutated form of huntingtin protein (mHTT). Recent findings suggest that presence of mHTT may affect one type of the double-strand DNA breaks repair, the non-homologous end joining. It is suggested that impairment of DSBs repair occurs long before clinical diagnostic of Huntington's disease.
Czech name
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Czech description
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Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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