Melanoma progression and spontaneous regression in the Melanoma-bearing Libechov Minipig (MeLiM) model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536610" target="_blank" >RIV/67985904:_____/20:00536610 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Melanoma progression and spontaneous regression in the Melanoma-bearing Libechov Minipig (MeLiM) model

Original language description

Cutaneous melanoma is a malignant tumour arising by neoplastic transformation of melanocytes, normal skin melanin-containing cells. It is the most dangerous skin cancer with worldwide incidence in Caucasian population increasing during the last decades. Despite present successes in the melanoma treatment using immune checkpoint inhibitors, its therapy in metastatic stage is still unsatisfactory and new approaches need to be sought. The Melanoma-bearing Libechov Minipig (MeLiM) is a unique model of hereditary metastatic melanoma which shows histopathological, immunohistochemical, biochemical, haematological, and genetic similarities with the human melanoma. Long-term monitoring and detailed analyses of affected animals allow identifying genes and understanding the biological processes associated with the melanoma development and progression as well as its spontaneous regression. In addition, new techniques for melanoma treatment can be tested using MeLiM piglets with progressing melanoma. Tumour devitalization (surgical ischaemization) was successfully utilized in animals with metastatic melanoma and multiple cutaneousntumours. Increased expression of heat shock proteins HSP70 and gp96 in the devitalized melanoma followed by increased population of tumour infiltrating lymphocytes in all untreated melanomas and generalized destruction of melanoma cells in all cancer deposits including organ metastases were observed in the treated pigs. They were in long-term remission without relapse. MeLiM represents a valuable large animal model to study melanoma regression and new methods for melanoma treatment.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Number of pages of the result

14

Pages from-to

187-200

Number of pages of the book

271

Publisher name

Academia

Place of publication

Praha

UT code for WoS chapter

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