Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00576044" target="_blank" >RIV/67985904:_____/23:00576044 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00134349 RIV/61989592:15110/23:73621295
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/jcla.24949" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jcla.24949</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcla.24949" target="_blank" >10.1002/jcla.24949</a>
Alternative languages
Result language
angličtina
Original language name
Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
Original language description
BackgroundInsulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. MethodsWe enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. ResultsThe G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. ConclusionOur results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Laboratory Analysis
ISSN
0887-8013
e-ISSN
1098-2825
Volume of the periodical
37
Issue of the periodical within the volume
13-14
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
e24949
UT code for WoS article
001036281600001
EID of the result in the Scopus database
2-s2.0-85166405685