Lithiated porous silicon nanowires stimulate periodontal regeneration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00582132" target="_blank" >RIV/67985904:_____/24:00582132 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-023-44581-5" target="_blank" >https://www.nature.com/articles/s41467-023-44581-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-023-44581-5" target="_blank" >10.1038/s41467-023-44581-5</a>
Alternative languages
Result language
angličtina
Original language name
Lithiated porous silicon nanowires stimulate periodontal regeneration
Original language description
Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/beta-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/beta-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA21-21409S" target="_blank" >GA21-21409S: Physiological properties and functions of dentition related stem cells with focus on in vivo context</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
487
UT code for WoS article
001142873900011
EID of the result in the Scopus database
2-s2.0-85182177983