Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00588031" target="_blank" >RIV/67985904:_____/24:00588031 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/24:43881230
Result on the web
<a href="https://link.springer.com/article/10.1007/s00424-024-02977-2" target="_blank" >https://link.springer.com/article/10.1007/s00424-024-02977-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00424-024-02977-2" target="_blank" >10.1007/s00424-024-02977-2</a>

Result language
angličtina
Original language name
Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells
Original language description
Osteoclasts are multinucleated cells of hematopoietic origin, with a pivotal role in bone development and remodeling. Failure in osteoclast differentiation and activation leads to various bone disorders, thus, attention has focused on a search of molecules involved in osteoclast regulatory pathways. Caspase-8 appears to be an interesting candidate for further exploration, due to its potential function in bone development and homeostasis. Mouse bone marrow cells were differentiated into osteoclasts by RANKL stimulation. Increased activation of caspase-8 and its downstream executioner caspases (caspase-3 and caspase-6) was found during osteoclastogenesis. Subsequent inhibition of caspase-8, caspase-3, or caspase-6, respectively, during osteoclast differentiation showed distinct changes in the formation of TRAP-positive multinucleated cells and reduced expression of osteoclast markers including Acp5, Ctsk, Dcstamp, and Mmp9. Analysis of bone matrix resorption confirmed significantly reduced osteoclast function after caspase inhibition. The results clearly showed the role of caspases in the proper development of osteoclasts and contributed new knowledge about non-apoptotic function of caspases.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/GA21-21409S" target="_blank" >GA21-21409S: Physiological properties and functions of dentition related stem cells with focus on in vivo context</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)