Dynamics and necessity of SIRT1 for maternal–zygotic transition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00599151" target="_blank" >RIV/67985904:_____/24:00599151 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/24:00599151 RIV/00216208:11110/24:10485240 RIV/00216208:11140/24:10485240
Result on the web
<a href="https://www.nature.com/articles/s41598-024-72595-6" target="_blank" >https://www.nature.com/articles/s41598-024-72595-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-72595-6" target="_blank" >10.1038/s41598-024-72595-6</a>
Alternative languages
Result language
angličtina
Original language name
Dynamics and necessity of SIRT1 for maternal–zygotic transition
Original language description
Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
21598
UT code for WoS article
001337075200069
EID of the result in the Scopus database
2-s2.0-85204237918