Widespread adaptive introgression of major histocompatibility complex genes across vertebrate hybrid zones

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00599799" target="_blank" >RIV/67985904:_____/24:00599799 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/24:00599799 RIV/00023272:_____/24:10136729

Result on the web

<a href="https://academic.oup.com/mbe/article-pdf/41/10/msae201/59744748/msae201.pdf" target="_blank" >https://academic.oup.com/mbe/article-pdf/41/10/msae201/59744748/msae201.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msae201" target="_blank" >10.1093/molbev/msae201</a>

Result language

angličtina

Original language name

Widespread adaptive introgression of major histocompatibility complex genes across vertebrate hybrid zones

Original language description

Interspecific introgression is a potentially important source of novel variation of adaptive significance. Although multiple cases of adaptive introgression are well documented, broader generalizations about its targets and mechanisms are lacking. Multiallelic balancing selection, particularly when acting through rare allele advantage, is an evolutionary mechanism expected to favor adaptive introgression. This is because introgressed alleles are likely to confer an immediate selective advantage, facilitating their establishment in the recipient species even in the face of strong genomic barriers to introgression. Vertebrate major histocompatibility complex genes are well-established targets of long-term multiallelic balancing selection, so widespread adaptive major histocompatibility complex introgression is expected. Here, we evaluate this hypothesis using data from 29 hybrid zones formed by fish, amphibians, squamates, turtles, birds, and mammals at advanced stages of speciation. The key prediction of more extensive major histocompatibility complex introgression compared to genome-wide introgression was tested with three complementary statistical approaches. We found evidence for widespread adaptive introgression of major histocompatibility complex genes, providing a link between the process of adaptive introgression and an underlying mechanism. Our work identifies major histocompatibility complex introgression as a general mechanism by which species can acquire novel, and possibly regain previously lost, variation that may enhance defense against pathogens and increase adaptive potential.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

<a href="/en/project/GA18-24544S" target="_blank" >GA18-24544S: ANGUIOMICS: Genomic insights into the evolutionary history and contact zones of slow-worm lizards (Anguis)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

1537-1719

Volume of the periodical

41

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

msae201

UT code for WoS article

001334598500001

EID of the result in the Scopus database

2-s2.0-85206400430