Caspase-12 affects chondrogenesis in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00618657" target="_blank" >RIV/67985904:_____/25:00618657 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/25:43881484
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0940960224001390?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0940960224001390?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aanat.2024.152347" target="_blank" >10.1016/j.aanat.2024.152347</a>
Alternative languages
Result language
angličtina
Original language name
Caspase-12 affects chondrogenesis in mice
Original language description
Caspase-12 is a molecule whose functions are still not well understood. Although its expression has been found in various tissues, specific roles have been described in only a few cases. These include the effect of caspase-12 on murine bone cell differentiation during craniofacial development. This work focused on the development of the limbs taking place through endochondral ossification, which precedes the formation of the cartilaginous growth plate. Caspase-12 was described here for the first time in growth plate chondrocytes during physiological development. Using pharmacological inhibition, caspase-12 was found to affect chondrogenesis. Limb-derived micromass cultures showed a significantly increased area of chondrogenic nodules after caspase-12 inhibition and there were changes in gene expression, the most significant of which was the reduction of Mmp9. These data point to potential new functions of caspase-12 in chondrogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of Anatomy-Anatomischer Anzeiger
ISSN
0940-9602
e-ISSN
1618-0402
Volume of the periodical
257
Issue of the periodical within the volume
Jan 25
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
152347
UT code for WoS article
001346123400001
EID of the result in the Scopus database
2-s2.0-85207281475