Demographic and selection histories of populations across the Sahel/Savannah belt

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F22%3A00563470" target="_blank" >RIV/67985912:_____/22:00563470 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10449903
Result on the web
<a href="https://academic.oup.com/mbe/article/39/10/msac209/6731090" target="_blank" >https://academic.oup.com/mbe/article/39/10/msac209/6731090</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/molbev/msac209" target="_blank" >10.1093/molbev/msac209</a>

Result language
angličtina
Original language name
Demographic and selection histories of populations across the Sahel/Savannah belt
Original language description
The study shows very complex patterns of genetic diversity between the populations from the Sahel/Savannah belt. The new findings improve our current knowledge of population structure, migration, admixture, and also adaptation of different human populations and shed new light on how selection may have influenced human adaptation to diseases, cultural factors, and environmental changes in Africa. The study also investigated genomic regions that were candidates for selection. For instance, in a population from Senegal (the Bedik) involved genes are associated with several rare blood disorders. Other Western African populations showed candidate regions of selection that were associated with malaria genes, lactase persistence, and immune response. In particular, a specific signal of exceptionally strong selection was detected in Eastern Sahel (the Rashaayda Arab) and this region involves the CNR1 gene, which was previously associated with substance dependence and responses to chronic stress. These findings are discussed in relation to archaeological and historical evidence regarding migrations and demographic changes in this part of Africa.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
60102 - Archaeology

Project
<a href="/en/project/GA19-09352S" target="_blank" >GA19-09352S: Genomic Adaptations and Molecular Ecology of Food Production Systems</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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