Troger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F06%3A00040254" target="_blank" >RIV/68081707:_____/06:00040254 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/06:00020163
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Troger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
Original language description
Head-to-head oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2, and poly(dC-dG)2 by NMR and ECD spectroscopies, and fluorescence probe displacement assay. The presented dimers prefer AT sequences, but show higher affinity to poly(dC-dG)2 than distamycin A. The (4R,9R) configuration of methanodiazocin bridge was found to be better suited for interaction with ct-DNA and poly(dA-dT)2 than (4S,9S) configuration.
Czech name
Skelet Trogerovy base v racemickém a chirálním stylu jako spojka pro tvorbu bidistamycinu. Syntéza a studie vazby k DNA
Czech description
Dimery 'head-to-head' oligo-N-methylpyrrole peptidu spojené methano[1,5]diazocinem byly připraveny v racemické a chirální formě. Jejich vazba k DNA byla studována s využitím DNA z telecího thymu, poly(dA-dT)2, and poly(dC-dG)2 pomocí NMR and ECD spektroskopie a kompetičních reakcí s využitím fluorescenční sondy. Dimery preferují AT sekvence, vykazují však vyšší afinitu k poly(dC-dG)2 než distamycin A. Konfigurace (4R,9R) methanodiazocinového můstku se jeví vhodnější pro interakci s DNA z telecího thymua poly(dA-dT)2 než konfigurace (4S,9S).
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tetrahedron
ISSN
0040-4020
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
36
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
8591-8600
UT code for WoS article
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EID of the result in the Scopus database
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