Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F07%3A00080772" target="_blank" >RIV/68081707:_____/07:00080772 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer
Original language description
In this paper we have investigated hypomethylation capacities of alpha and beta anomers of 5-aza-2'-deoxycytidine. Surprisingly, alpha anomer induced DNA hypomethylation of the extent comparable with that of beta anomer. However, alpha anomer appeared tobe approx. 5 x less toxic than the beta anomer in leukemic cells in vitro. Thus alpha anomer seems to be a promising agent for epigenetic therapy.
Czech name
Stanovení hypometylačních účinků alfa a beta anomeru 5-aza-2'-deoxycytidinu
Czech description
V této práci jsme zkoumali hypometylační schopnosti alfa a beta anomeru 5-aza-2'-deoxycytidine. Překvapivě alfa anomer indukoval hypometylaci DNA v rozsahu srovnatelném s beta anomerem. Při aplikaci na leukemické buňky in vitro byl alfa anomer 5 x méně toxický nežli beta anomer. Alfa anomer by se tak mohl stát slibnou látkou pro epigenetickou terapii.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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