Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F08%3A00306732" target="_blank" >RIV/68081707:_____/08:00306732 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine

Original language description

Cytotoxicity and mutagenicity of trans,trans,trans-[PtCl2(CH3COO)2(NH3)(1-adamantylamine)] [trans-adamplatin(IV)] and its reduced analog trans-[PtCl2(NH3)(1-adamantylamine)] [trans-adamplatin(II)] were examined. A notable feature of the growth inhibitionstudies was the remarkable circumvention of both acquired and intrinsic cisplatin resistance by the two lipophilic trans-compounds. The results also demonstrate that trans-adamplatin(II) exhibits DNA binding mode markedly different from that of ineffective transplatin.

Czech name

Cytotoxicita, mutagenicita, buněčný příjem, interakce s DNA a glutathionem lipofilních komplexů transplatiny připojených k 1-adamantylaminu

Czech description

Byly studovány cytotoxicita a mutagenicita komplexů of trans,trans,trans-[PtCl2(CH3COO)2(NH3)(1-adamantylamine)] [trans-adamplatin(IV)] and its reduced analog trans-[PtCl2(NH3)(1-adamantylamine)] [trans-adamplatin(II)]. Pozoruhodným rysem studií zaměřených na inhibici růstu buněk bylo pozoruhodné obejití jak zíkané tak vlastní rezistence k cisplatině. Výsledky také ukazují, že komplex trans-adamplatin(II) vykazuje vazebné vlastnosti k DNA výrazně odlišné ve srovnání s cisplatinou.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

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Volume of the periodical

102

Issue of the periodical within the volume

5-6

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

1077-1089

UT code for WoS article

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EID of the result in the Scopus database

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