Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00456660" target="_blank" >RIV/68081707:_____/15:00456660 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.07.014" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2015.07.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.07.014" target="_blank" >10.1016/j.jinorgbio.2015.07.014</a>

Result language
angličtina
Original language name
Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?
Original language description
The effects of the two representatives of the antitumor transplatinum agents, trans-[PtCl2(methylamine)(2)] and trans-[PtCl2(NH3)(1-methyl-7-azaindole)] on bacterial growth were examined. The results show that these antitumor transplatinum agents can begrouped with the coordination Pt(II) compounds exhibiting antitumor activity and capable of inducing bacterial filamentation and initiate lysis in lysogenic bacteria. The results corroborate the thesis that DNA is the potential cellular target also for aclass of antitumor derivatives of transplatin. (C) 2015 Elsevier Inc. All rights reserved.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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