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Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F08%3A00306741" target="_blank" >RIV/68081707:_____/08:00306741 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/08:00024573

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis

  • Original language description

    Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to a therapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monoblasts induced by arsenic trioxide, cycloheximide and camptothecin with U937 promonocytes as a reference cell line. We show that induced death of BM2 cells is not executed by caspases but rather by alternative cell death pathways.

  • Czech name

    Aktivace alternativních drah programované buněčné smrti u buněk s defektní apoptózou závislou na kaspázách

  • Czech description

    Ztráta funkčnosti dráhy vedoucí k programované buněčné smrti je jeden z procesů provázející vznik malignit a komplikující účinnost protinádorové terapie. Analyzovali jsme dráhy vedoucí k buněčné smrti po působení oxidu arsenitého, cykloheximidu a kamptotecinu u monoblastů BM2 transformovaných onkogenem v-myb a promonocytů U937. Prokázali jsme, že indukce buněčné smrti u BM2 buněk není spojena s aktivací kaspáz, ale vede přes alternativní dráhy buněčné smrti.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia Research

  • ISSN

    0145-2126

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    599-609

  • UT code for WoS article

  • EID of the result in the Scopus database