Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F13%3A00440144" target="_blank" >RIV/68081707:_____/13:00440144 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/13:00440144

Result on the web

<a href="http://dx.doi.org/10.2217/EPI.13.38" target="_blank" >http://dx.doi.org/10.2217/EPI.13.38</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/EPI.13.38" target="_blank" >10.2217/EPI.13.38</a>

Result language

angličtina

Original language name

Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors

Original language description

Aim: The optimal balance between histone acetylation and deacetylation is important for proper gene function. Therefore, we addressed how inhibitors of histone-modifying enzymes can modulate nuclear events, including replication, transcription, splicingand DNA repair. Materials & methods: Changes in cell signaling pathways upon treatment with histone acetyltransferases and/or histone deacetylase inhibitors were studied by cDNA microarrays and western blots. Results: We analyzed the effects of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and the histone acetylase inhibitor MG149. SAHA altered the expression of factors involved in DNA replication complexes, basal transcription and the spliceosome pathway. DNA repair-related genes, including Rad51, Rad54 and BRCA2, were significantly downregulated by SAHA. However, MG149 had no effect on the investigated nuclear processes, with the exception of the spliceosome network and Sestrins, involved in DNA repair. Conc

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epigenomics

ISSN

1750-1911

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

379-396

UT code for WoS article

000330537900009

EID of the result in the Scopus database

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