Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00435169" target="_blank" >RIV/68081707:_____/14:00435169 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/14:00082028
Result on the web
<a href="http://dx.doi.org/10.1155/2014/848632" target="_blank" >http://dx.doi.org/10.1155/2014/848632</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/848632" target="_blank" >10.1155/2014/848632</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
Original language description
Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family(TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary P
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mediators of Inflammation
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
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UT code for WoS article
000335742300001
EID of the result in the Scopus database
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