Novel trisubstituted acridines as human telomeric quadruplex binding ligands

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00439913" target="_blank" >RIV/68081707:_____/14:00439913 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bioorg.2014.07.010" target="_blank" >http://dx.doi.org/10.1016/j.bioorg.2014.07.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bioorg.2014.07.010" target="_blank" >10.1016/j.bioorg.2014.07.010</a>

Result language

angličtina

Original language name

Novel trisubstituted acridines as human telomeric quadruplex binding ligands

Original language description

A novel series of trisubstituted acridines were synthesized with the aim of mimicking the effects of BRACO-19. These compounds were synthesized by modifying the molecular structure of BRACO19 at positions 3 and 6 with heteroacyclic moieties. All of the derivatives presented in the study exhibited stabilizing effects on the human telomeric DNA quadruplex. UV-vis spectroscopy, circular dichroism, linear dichroism and viscosimetry were used in order to study the nature of the DNA binding in more detail. The results show that all of the novel derivatives were able to fold the single-stranded DNA sequences into antiparallel G-quadruplex structures, with derivative 15 exhibiting the highest stabilizing capability. Cell cycle analysis revealed that a primarytrend of the "braco"-like derivatives was to arrest the cells in the Sand G(2)M-phases of the cell cycle within the first 72 h, with derivative 13 and BRACO19 proving particularly effective in suppressing cell proliferation. All studies d

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic Chemistry

ISSN

0045-2068

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

DEC 2014

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

13-29

UT code for WoS article

000345698000003

EID of the result in the Scopus database

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