Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00440095" target="_blank" >RIV/68081707:_____/14:00440095 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/anie.201408012" target="_blank" >http://dx.doi.org/10.1002/anie.201408012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/anie.201408012" target="_blank" >10.1002/anie.201408012</a>

Result language

angličtina

Original language name

Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity

Original language description

The trinuclear platinum complexes (Triplatin NC-A [{Pt(NH3)(3)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](6+), and Triplatin NC [{trans-Pt(NH3)(2)(NH2(CH2)(6)NH3+)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](8+)) are biologically active agents thatbind to DNA through noncovalent (hydrogen bonding, electrostatic) interactions. Herein, we show that TriplatinNC condenses DNAwith a much higher potency than conventional DNA condensing agents. Both complexes induce aggregation of small transfer RNA molecules, and TriplatinNC in particular completely inhibits DNA transcription at lower concentrations than naturally occurring spermine. Topoisomerase Imediated relaxation of supercoiled DNA was inhibited by TriplatinNC-A and TriplatinNC at concentrations which were 60 times and 250 times lower than that of spermine. The mechanisms for the biological activity of TriplatinNC-A and TriplatinNC may be associated with their ability to condense/aggregate nucleic acids with consequent inhibitory

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GA13-08273S" target="_blank" >GA13-08273S: Biophysical analysis of DNA condensation. Effect of new organometallic compounds of biological significance.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Angewandte Chemie - International Edition

ISSN

1433-7851

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

47

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

12812-12816

UT code for WoS article

000344793400023

EID of the result in the Scopus database

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