Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00461853" target="_blank" >RIV/68081707:_____/16:00461853 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/16:00111637
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbamcr.2016.04.026" target="_blank" >http://dx.doi.org/10.1016/j.bbamcr.2016.04.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbamcr.2016.04.026" target="_blank" >10.1016/j.bbamcr.2016.04.026</a>
Alternative languages
Result language
angličtina
Original language name
Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy
Original language description
Mitochondria play a pivotal role in apoptosis: permeabilization of the outer mitochondria! membrane and the release of pro-apoptotic proteins from the intermembrane space of mitochondria are regarded as the key event in apoptosis induction. Here we demonstrate how non-toxic doses of the mitochondrial Complex II inhibitor thenoyltrifluoroacetone (TTFA), which specifically inhibits the ubiquinone-binding site of succinate dehydrogenase (SDH), synergistically stimulated cell death, induced by harmless doses of cisplatin in a panel of chemoresistant neuroblastoma cell lines. Apoptotic cell death was confirmed by cytochrome c release from the mitochondria, cleavage of poly ADP-ribose polymerase, processing of caspase-3, which is an important executive enzyme in apoptosis, and caspase-3-like activity. Methyl malonate, an inhibitor of the SDHA subunit partially reversed apoptosis stimulated by TTFA in SK-N-BE(2) neuroblastoma cells (NB), indicating that sensitization requires oxidation of succinate.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica Et Biophysica Acta-Molecular Cell Research
ISSN
0167-4889
e-ISSN
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Volume of the periodical
1863
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
2065-2071
UT code for WoS article
000378671900012
EID of the result in the Scopus database
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