Wild-type p53 binds to MYC promoter G-quadruplex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471953" target="_blank" >RIV/68081707:_____/16:00471953 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1042/BSR20160232" target="_blank" >http://dx.doi.org/10.1042/BSR20160232</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BSR20160232" target="_blank" >10.1042/BSR20160232</a>

Result language

angličtina

Original language name

Wild-type p53 binds to MYC promoter G-quadruplex

Original language description

G-quadruplexes are four-stranded nucleic acid structures that are implicated in the regulation of transcription, translation and replication. Genome regions enriched in putative G-quadruplex motifs include telomeres and gene promoters. Tumour suppressor p53 plays a critical role in regulatory pathways leading to cell cycle arrest, DNA repair and apoptosis. In addition to transcriptional regulation mediated via sequence-specific DNA binding, p53 can selectively bind various non-B DNA structures. In the present study, wild-type p53 (wtp53) binding to G-quadruplex formed by MYC promoter nuclease hypersensitive element (NHE) III1 region was investigated. Wtp53 binding to MYC G-quadruplex is comparable to interaction with specific p53 consensus sequence (p53CON). Apart from the full-length wtp53, its isolated C-terminal region (aa 320-393) as well, is capable of high-affinity MYC G-quadruplex binding, suggesting its critical role in this type of interaction. Moreover, wtp53 binds to MYC promoter region containing putative G-quadruplex motif in two wtp53-expressing cell lines. The results suggest that wtp53 binding to G-quadruplexes can take part in transcriptional regulation of its target genes.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioscience Reports

ISSN

0144-8463

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

OCT2016

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

—

UT code for WoS article

000388364900021

EID of the result in the Scopus database

—