Recognition of Local DNA Structures by p53 Protein

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00485741" target="_blank" >RIV/68081707:_____/17:00485741 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/ijms18020375" target="_blank" >http://dx.doi.org/10.3390/ijms18020375</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms18020375" target="_blank" >10.3390/ijms18020375</a>

Result language

angličtina

Original language name

Recognition of Local DNA Structures by p53 Protein

Original language description

p53 plays critical roles in regulating cell cycle, apoptosis, senescence and metabolism and is commonly mutated in human cancer. These roles are achieved by interaction with other proteins, but particularly by interaction with DNA. As a transcription factor, p53 is well known to bind consensus target sequences in linear B-DNA. Recent findings indicate that p53 binds with higher affinity to target sequences that form cruciform DNA structure. Moreover, p53 binds very tightly to non-B DNA structures and local DNA structures are increasingly recognized to influence the activity of wild-type and mutant p53. Apart from cruciform structures, p53 binds to quadruplex DNA, triplex DNA, DNA loops, bulged DNA and hemicatenane DNA. In this review, we describe local DNA structures and summarize information about interactions of p53 with these structural DNA motifs. These recent data provide important insights into the complexity of the p53 pathway and the functional consequences of wild-type and mutant p53 activation in normal and tumor cells.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA15-21855S" target="_blank" >GA15-21855S: Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

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UT code for WoS article

000395457700143

EID of the result in the Scopus database

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