Organoruthenium Complexes with CN Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00486061" target="_blank" >RIV/68081707:_____/17:00486061 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73583775
Result on the web
<a href="http://dx.doi.org/10.1002/chem.201703581" target="_blank" >http://dx.doi.org/10.1002/chem.201703581</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201703581" target="_blank" >10.1002/chem.201703581</a>
Alternative languages
Result language
angličtina
Original language name
Organoruthenium Complexes with CN Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action
Original language description
Our study demonstrates that four novel kinetically inert C,N-cyclometalated Ru-II complexes of the type [Ru(C<^>N)(N<^>N)(2)][PF6] containing a handle for functionalization on the C<^>N ligand are very potent cytotoxic agents against several different human cancer cell lines and are up to 400-fold more potent than clinically used cisplatin. In addition, the investigated ruthenium complexes are less cytotoxic in noncancerous cells, and exhibit higher selectivity for cancer cells than conventional platinum anticancer drugs. The high potency of the investigated ruthenium compounds can be attributed to several factors, including enhanced internalization and their capability to change mitochondrial transmembrane potential in cells. The new ruthenium complexes also interfere with protein synthesis with a markedly higher potency than conventional inhibitors of DNA translation. Notably, the latter mechanism has not been hitherto described for other cytotoxic Ru compounds and cisplatin.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA17-05302S" target="_blank" >GA17-05302S: Targeting cancer stem cells by antitumor metallodrugs. Studies on mechanism of action</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
61
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
15294-15299
UT code for WoS article
000414351400006
EID of the result in the Scopus database
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