Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00502720" target="_blank" >RIV/68081707:_____/18:00502720 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/18:73589836
Result on the web
<a href="http://dx.doi.org/10.1039/c7nj04711h" target="_blank" >http://dx.doi.org/10.1039/c7nj04711h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7nj04711h" target="_blank" >10.1039/c7nj04711h</a>
Alternative languages
Result language
angličtina
Original language name
Half-sandwich type rhodium(III)-aminohydroxamate complexes: the role of the position of the amino group in metal ion binding
Original language description
Complex formation equilibria between [(eta(5)-Cp*) Rh-III(H2O)(3)](2+) and aminohydroxamic acids (L-2-aminoN-hydroxyacetamide (alpha-alahaH), 3-amino-N-hydroxypropanamide (beta-alahaH) and 4-amino-N-hydroxybutanamide (GABAha, gamma-abhaH)) having the primary amino group in different chelatable positions relative to the hydroxamic function were studied using pH-potentiometric, H-1 NMR and ESI-MS methods and the formation constants of the complexes present in aqueous solution are reported. The relative order of the pH-dependent conditional stability of the hydroxamate type (O,O) and (N-amino, N-hydroxamato) chelates was found to determine to a great extent the coordination modes both in the mono-and various dinuclear species formed. While with alpha-alaha(-), a 5-membered (N,N) chelated mononuclear complex predominates, with beta-alaha-in a wide pH-range, very stable dinuclear cluster ions exist. With gamma-abha(-), in the most stable complexes, two ligands (in reverse variation) link two half-sandwich cations, coordinating each ligand via the hydroxamate chelate to one metal centre, while via the amino-N to the other one. This arrangement seems to be further stabilized by a hydrogen bond as DFT calculations support the extra stabilization effect of internal H-bonding in [{(eta(5)-Cp*) Rh-III}(2)H1(gamma-abha)(2)](+). The synthesis, spectral (NMR and IR) and MS characterization of a novel complex with an iridium analogue, [(eta(5)-Cp*) Ir-III(alpha-alaha) Br] (1) is also described. This complex was tested for its in vitro cytotoxicity using human-derived cancer cell lines (A2780, HeLa, DU-145, A549, and MCF-7) and showed insignificant anti-proliferative activity in the micromolar concentration range.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New Journal of Chemistry
ISSN
1144-0546
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
7659-7670
UT code for WoS article
000434245500019
EID of the result in the Scopus database
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