Systematic investigation of sequence requirements for DNA i-motif formation.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00502911" target="_blank" >RIV/68081707:_____/19:00502911 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/nar/article-pdf/47/5/2177/28041982/gkz046.pdf" target="_blank" >https://academic.oup.com/nar/article-pdf/47/5/2177/28041982/gkz046.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkz046" target="_blank" >10.1093/nar/gkz046</a>
Alternative languages
Result language
angličtina
Original language name
Systematic investigation of sequence requirements for DNA i-motif formation.
Original language description
The formation of intercalated motifs (iMs) - secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption spectra. By means of spectroscopic methods, electrophoresis, chemical modifications and other procedures, we characterized iM formation and stability in sequences with different cytosine block lengths interrupted by various numbers and types of nucleotides. Particular attention was paid to the formation of iMs at pH conditions close to neutral. We identified the optimal conditions and minimal requirements for iM formation in DNA sequences, and addressed gaps and inaccurate data interpretations in existing studies to specify principles of iM formation and modes of their folding.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
1362-4962
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
MAR2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
2177-2189
UT code for WoS article
000467963700010
EID of the result in the Scopus database
2-s2.0-85062859535